Welcome to the Gold Lab at UNM
Understanding bioorganic structure and reactivity for the precise control of molecular properties and transformations

Collaborative Efforts

Coming soon…

SNO-OCTs! (See also: bioorthogonal 1,3-dipolar cycloadditions):
Burke, E. G.;* Gold, B.;* Hoang, T. T.; Raines, R. T.; Schomaker, J. M. Fine-Tuning Strain and Electronic Activation of Strain-Promoted 1,3-Dipolar Cycloadditions with Endocyclic Sulfamates in SNO-OCTS. J. Am. Chem. Soc. 2017, 139, 8029.

Alkynogenic Fragementations:
Batsomboon, P.; Gold, B.; Alabugin, I. V.;  Dudley, G. B. Tandem Nucleophilic Addition/Fragmentation of Vinylogous Acyl Nonaflates for the Synthesis of Functionalized Alkynes, with a Key Mechanistic Insight. Synthesis, 2012, 44, 1818.

Alkyne Cyclizations:
4. Baranov, D. S.; Gold, B.; Vasilevsky, S. F.; Alabugin, I. V. Divergent Cyclizations of 1-R-Ethynyl-9,10-anthraquinones:  Use of Thiourea as a “S2-” Equivalent in an “Anchor-Relay” Addition Mediated by Formal C–H Activation. J. Org. Chem. 2013, 78, 2074.
3. Vasilevsky, S. F.; Gold, B.; Mikhailovskaya, T. F.; Alabugin, I. V. Strain Control in Nucleophilic Cyclizations: Reversal of exo-Selectivity in Cyclizations of Hydrazides of Acetylenyl Carboxylic Acids by Annealing to a Pyrazole Scaffold. J. Phys. Org. Chem. 2012, 25, 998.
2. Baranov, D. S.; Vasilevsky, S. F.; Gold, B.; Alabugin, I. V. Urea as a Solvent and Reagent for the Addition/Cyclization/Fragmentation Cascades Leading to 2-R-7H-dibenzo[de,h]quinolin-7-one Analogues of Aporphinoid Alkaloids. RSC Adv. 2011, 1, 1745.
1. Stepanov, A. A.; Gornostaev, L. M.; Vasilevsky, S. F.; Arnold, E. V.; Mamatyuk, V. I.; Fadeev, D. S.; Gold, B.; Alabugin, I. V. Chameleonic Reactivity of Vicinal Diazonium Salt of Acetylenyl-9,10- Anthraquinones: Synthetic Application Towards Two Heterocyclic Targets. J. Org. Chem. 2011, 76, 8737.